Identification of Rabbit Myostatin Gene Polymorphisms
نویسندگان
چکیده
منابع مشابه
Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9
CRISPR/Cas9 has been widely used in generating site-specific genetically modified animal models. Myostatin (MSTN) is a negative regulator of muscle mass, related to muscle growth and differentiation. The knockout of MSTN with the desired phenotype of double muscle has been successfully generated in mice, goats, pigs and cattle, but not in rabbits. In this study, the MSTN knockout (KO) rabbits w...
متن کاملAnalysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types
Myostatin (MSTN) is a negative modulator of muscle mass. We characterized the horse (Equus caballus) MSTN gene and identified and analysed single nucleotide polymorphisms (SNPs) in breeds of different morphological types. Sequencing of coding, untranslated, intronic, and regulatory regions of MSTN gene in 12 horses from 10 breeds revealed seven SNPs: two in the promoter, four in intron 1, and o...
متن کاملThe Myostatin Gene
Myostatin is an important negative regulator of muscle growth. Natural mutations and knockouts in animals produce a “double-muscled” phenotype the basis of which is a dramatic increase in muscle mass. Therapeutics that target myostatin are currently in development. There are almost no documented side effects of suppression, and early research suggests that myostatin inhibition can restore funct...
متن کاملPolymorphisms of the myostatin gene (MSTN) and its relationship with growth traits in goat breeds.
Mutations in the myostatin (MSTN) gene can inactivate its expression and result in a non-functional protein, which leads to dramatic muscularity and a "double-muscling" phenomenon in many species. Using gene sequencing and polymerase chain reaction-single-strand conformation polymorphism methods, polymorphisms of the MSTN gene were investigated as a candidate marker for growth in 288 goats. The...
متن کاملRabbit MSTN gene polymorphisms and genetic effect analysis.
We analyzed meat samples of nine pure lines of rabbit and its 37 hybrid combinations by sequencing and single-strand conformation polymorphism techniques to explore genetic polymorphisms of all the three exon regions and part of the 5'-regulatory region of the myostatin (MSTN) gene. Thus, we detected a single nucleotide mutation (T→C) on the 476 locus of the 5'-regulatory region, but no mutatio...
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ژورنال
عنوان ژورنال: Media Peternakan
سال: 2015
ISSN: 0126-0472,2087-4634
DOI: 10.5398/medpet.2015.38.2.77